Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology

It was shown by the conductometric study that formation of micelles in cetyltrimethylam¬monium bromide (CTAB) – dimethylsulfoxide (DMSO) water system occurs at higher critical micelle concentrations (CMC) than CTAB system. The solubilization nitroxoline this upon reaching CMC determined spectrophotometric method. Box–Behnken design used to obtain systems with highest light absorption nitroxoline, depending on concentration, acidity pH medium, and proportion DMSO when searching for optimal matrix. A sensitive selective technique suitable micellar media analysis developed using response surface methodology determination medicines.